10 Products Gene ID: Human(3156) Summary: HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback

2021-04-06

View mouse Hmgcr Chr13:96648967-96670936 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression. Home. Blood lipid genetic scores, the HMGCR gene and cancer risk: A Mendelian randomization study. International Journal of Epidemiology, 47(2), 495-505.

Hmgcr gene

Copy Number Determination. HMGCR chr5. dHsaCP1000430. FAM. 65. Copy Number Determination. Candidate genes . We aim to study the role of the obesity-linked gene and statin target HMGCR in endocrine, neuronal and muscular Worked on the HMGCR gene in DrosophilaMelanogaster(Fruit fly) I had done my Bachelor degree project as Genetic counsellor under Dr .

Implications. This is the first study linking pig 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) expression levels with carcass and meat quality traits.This gene, which codes for the limiting enzyme in the de novo synthesis of cholesterol, regulates plasma lipid levels and cholesterol uptake in humans.

As in the hamster Hmgcr gene, this upstream region provides sites for statin-dependent induction and sterol-dependent suppression. Searching the mammalian genome databases with the protein sequence of human HMGCR revealed only a single HMGCR gene in all three genomes, i.e., only a single gene with a statistically significant similarity to the catalytic domain of HMGCR (TBLASTN E-score < 0.001). The human gene is localized at 5q13.3-q14.3 and the rodent homologs are found However, gene encoding HMGCR remains unchanged regardless of the type of dietary feeding assays.

Gene name. HMGCR : Synonyms. Description. 3-hydroxy-3-methylglutaryl-CoA reductase (HGNC Symbol) Entrez gene summary

KJ891361 - Synthetic construct Homo sapiens clone ccsbBroadEn_00755 HMGCR gene, encodes complete protein.

LF332352 - JP 2014500723-A/139855: Polycomb-Associated Non-Coding RNAs. 2018-12-03 · First, Cmpd 81 selectively eliminates HMGCR without up-regulating the expression of fatty acid biosynthetic master gene, SREBP-1c (Supplementary Fig. 5), avoiding the side effects caused by HMGCR Antibodies Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik2, also known as glutamate receptor 6, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Functional Associations. HMGCR has 7,668 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 84 datasets.
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Summaries for HMGCR gene (According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL) About This Sectio Gene name. HMGCR : Synonyms. Description. 3-hydroxy-3-methylglutaryl-CoA reductase (HGNC Symbol) Entrez gene summary.

Unique Assay ID 68. Copy Number Determination.
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KJ891361 - Synthetic construct Homo sapiens clone ccsbBroadEn_00755 HMGCR gene, encodes complete protein. AK312437 - Homo sapiens cDNA, FLJ92784, highly similar to Homo sapiens 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (HMGCR), mRNA. LF332352 - JP 2014500723-A/139855: Polycomb-Associated Non-Coding RNAs.

However, gene encoding HMGCR remains unchanged regardless of the type of dietary feeding assays. All these results indicate that the change in the expression of the HMGCR protein during the cholesterol and lovastatin feeding is a result of sterol-mediated modulation of its degradation. HMGCR: Description: 3-hydroxy-3-methylglutaryl-CoA reductase [Source:HGNC Symbol;Acc:HGNC:5006] Organism: Homo sapiens: Synonym(s) b7z3y9, ldlcq3, q8n190 2021-03-06 · Cholesterol synthesis was blocked in culture by inhibiting the activity of HMG CoA reductase (HMGCR) resulting in germ cell survival and migration defects renal ischemia/reperfusion activates the HMGCR gene via multiple stress-activated transcriptional and epigenetic pathways, contributing to renal cholesterol loading. Gene name.

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The Hmgcr gene product has a critical developmental function in providing spatial information to guide migrating primordial germ cells. ( Van Doren et al., 1998 ) The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(w hs )} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation.

2021-01-22 A single nucleotide polymorphism in the 3-hydroxy-3-methylglutaryl-coenzyme A reductase gene (HMGCR) influences the serum triacylglycerol relationship with dietary fat and fibre in the European Prospective Investigation into Cancer and Nutrition in Norfolk (EPIC-Norfolk) study - Volume 104 Issue 5 Summaries for HMGCR gene (According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL) About This Sectio 2011-01-31 2017-11-20 Gene name.

5 Mar 2021 HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase) is a Protein Coding gene. Diseases associated with HMGCR include Familial

Orsaken till IMNM är okänd med positiva anti-HMGCR antikroppar rentiation-associated gene 5 is a major autoantigen in av A Miettinen — differentiation associated gene 5). SAE-antikroppar. NXP2-antikroppar. TIF1γ-antikroppar.

Gene name. HMGCR : Synonyms. Description.